Evaluate the propylthiouracil on thyroid, liver and kidney functions in male rabbits

Abstract

This work was conducted to investigate the effect of Propylthiouracil thyroid kidney and liver functions in male rabbits. Fifteen (15) rabbits were divided into three groups: a control group, which received tap water only, a low-dose group that received 50 mg/kg oral propylthiouracil and a high-dose group, which received 100 mg/kg oral propylthiouracil. Rabbits were dosed daily for three weeks. After the three-weeks period, the rabbits were sacrificed and blood samples were collected for hormonal and biochemical analysis. Showed changes in liver enzymes as a result of liver tissue damage. Propylthiouracil caused an increase in creatinine concentration, alkaline phosphatase levels, and liver enzyme levels. PTU treatment had no significant effect on the mean urea concentration level. In view of the changes summarized, the increase or decrease in this parameter arises from the reduction in the level of thyroid hormones which, in turn, affect most body tissues.