Seroprevalence rates of transfusion-transmitted infections among blood donors in Northeast of Libya
DOI:
https://doi.org/10.37376/1571-000-019-009الكلمات المفتاحية:
HIV، HBsAg، HCV، Syphilis، Infectious pathogens، Blood donors، Libyaالملخص
Blood transfusion is a life- saving therapeutic intervention that plays a crucial role in the overall management of patients. Transfusion-transmissible infectious agents such as human hepatitis B virus (HBV), hepatitis C virus (HCV), immunodeficiency virus (HIV) and Syphilis are among the greatest threats to blood safety for recipients and WHO has recommended that these diseases should be screened to get safe blood. This study aimed to evaluate the prevalence of transfusion-transmissible infections (TTI) among donors at central blood bank and compare it with other studies. A retrospective analysis of consecutive blood donor’s records covering the period between 2008 and 2015 was conducted to analyse for seroprevalence of HBV, HCV, HIV and Syphilis among blood donors. The number of donors among eight years was 5487, 5217, 5916, 7967, 8604, 14335, 16821 and 14631 respectively. Sterile venous anti-coagulated blood was collected from the donors and analysed using highly sensitive and specific kits. Among 78987donors, the prevalence of HBsAg was 0.21%, and of anti-HCV was 0.24%. Very low percentages (0.014%) were positive for anti-HIV or anti-Syphilis. The overall seroprevalence of HBV, HCV, HIV and Syphilis was 0.12%, 0.24%, 0.014% and 0.014% respectively. Among those with multiple infections, the most common combinations were HBV and HCV. Moreover, significantly changeable trends of HIV and Syphilis seropositivity were observed over the study period. A percentage of the blood donors harbour HIV, HBV, HCV and Syphilis infections estimated the expected exclusion rate of transfusion-transmissible infections positive donated blood, as this would be an important factor to consider before donation.
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