Response Of Ovarian And Uterine Morphological-Functional Features To Gonadotropins In Dexamethasone Treated Adult Mice

Abstract

This study aimed at investigating the possibility of reversing the
adverse effects, on the reproductive system, that are associated with the
administration of synthetic glucocorticoids. Cycling Swiss albino mice
were divided into four groups, 12 mice each. Control mice were daily
intramuscularly injected with 0.1 ml normal physiological saline solution
for ten days. Mice of the Gonadotropins group received six daily
injections of 0.1 ml normal saline solution followed by three daily
injections of the gonadotropins: 04 IU FSH activity on the seventh and
ninth days, whereas 05 IU LH activity was administered on the tenth day.
Mice of the Dexamethasone group were daily injected with 02 ug of the
synthetic glucocorticoid for six days, followed by daily injections of 0.1
ml normal saline solution for four days. Animals of the Dexamethasone –
Gonadotropins group were treated with Dexamethasone for the first six
days followed by three daily injections of the Gonadotropins as described
above. On the eleventh day, animals were euthanized with ether and
weighed. Ovaries and uteri were dissected out, weighed and out into a
tissue fixative solution to prepare stained sections.