Retrospective Clinicopathological Study of 33 Cases of Pleomorphic Salivary Adenoma Diagnosed in Benghazi

Abstract

Background: Pleomorphic salivary adenoma (PSA) is the most frequently found neoplastic tumor in major and minor salivary glands. It has a high recurrence rate and there is a possibility for benign PSA to transform into malignant form. No study on clinical and histopathological features of pleomorphic adenoma in Libya was found. occurrence of benign PSA is more common than PSA with malignant foci.

Aim: The present study aimed to retrospectively analyze the clinical and histopathological features of cases diagnosed as pleomorphic adenoma and compare our findings to those of other studies.

Materials and Methods: In this retrospective study, the pleomorphic salivary adenoma cases diagnosed between 1994-2019 in the Department of Oral Pathology, Dental School, University of Benghazi, Libya were retrieved. The diagnosis was confirmed by reevaluation of hematoxylin and eosin-stained slides. Descriptive statistics were used to describe the clinical data of the patient’s demographics and clinical features of the tumor.

Results: It was found that among 33 diagnosed cases of PSA, 11 cases were males and 22 cases were females.  The most common age range was 10-29 years (21 cases). The most common intra-oral site was the palate (15 cases) followed by buccal mucosa (6 cases) and submandibular glands and parotid glands were most commonly affected among major salivary glands.  Benign pleomorphic adenoma (24 cases) was most common, myoepithelium was reported in 2 cases and malignant foci were reported in 7 cases.

Conclusion: This study revealed that Females were more affected than males. The most common location of pleomorphic adenoma was the palate. The myoepithelioma is a rare.