Acute nephrotoxicity of platinum in albino mice

Abstract

platinum (CDDP) is a potent anticancer agents used for the treatment of solid tumors. However, its clinical use is often limited by its adverse effects including nephrotoxicity. The present study was designed to estimate if Royal Jelly can inhibit or at least ameliorate the alteration in some renal function and structures induced by Cisplatin in mice or not. Four equal groups of mice: control, RJ-treated (300mg/kg, once oral dose/ 10 days), CP-treated (7 mg/kg once i.p. on day 11th.), combined RJ and CP-treated were used. Body and kidneys weights of each mouse were calculated. Serum levels of kidney biomarkers were assessed. Urea and Creatine levels. Renal samples from each mouse were prepared for light and electron microscopic examinations. Hemorrhage, glomerular atrophy, inflammatory cell infiltration, tubular necrosis and degeneration were observed in CP-treated mice. Also, a significant (P<0.05)increase in Urea &Creatine levels were determined in CP-treated mice compared to control group. However, most of CP-induced histomorphological, ultrastructural and biochemical changes were improved in animals pretreated with RJ. These results suggested that the effects of Cisplatin on renal function and structures could be totally or to a great extent inhibited by Royal Jelly.