Antioxidant properties of indole-3-carbinol on hepatotoxicity induction in experimental animals

Abstract

Indole-3-carbinol was found to have possible anticarcinogenic, antioxidant and
antiatherogenic effects on the organism. The aim of the present study investigation is to
evaluate the protective effect of indole-3-carbinol (I3C) against aspirin (ASA) induced effects
on rat liver. Male albino rats were randomly divided into four groups of 6 animals in each. The
control rats (group 1) were orally administration of distilled water for seven days and the
experimental rats (groups 2-4) were treated with ASA at a dose of 500 mg/kg/body weight and
I3C at a dose of 20 mg/kg/body weight either alone or in combination with each other orally,
once daily for seven consecutive days. Results of the present study showed that groups treated
with indole-3-carbinol possessed protective activity possibly as evidenced by the reduction of
histopathological alteration and showed normal histological structure of liver. This work
suggest that I3C possesses significant hepatoprotective and antioxidant properties on
hepatotoxicity induction by ASA in male albino rats.