Sperm abnormality toxicity due to Methotrex in male rat rats

Abstract

Methotrexate commonly used to treat cancer and caused reproductive damage in mice , . In this study, the effects of methotrexate on some parameters of sperms on mice testis after 35 days of MTX administration intraperitoneally (ip). twelve adult male mice were divided into control and treated groups composed of 6 mice in each group. Treated group received methotrexate in dose i.e 20mglkg, whereas control one received normal saline intraperitoneally, the results showed significant (P<0.05) increased percentage of abnormalities of sperms in mice treated with MTX compared to control, these data suggested that MTX administration induced sperm shape abnormalities.