Studying of some proteins levels and enzymes activities in the amniotic fluid for pregnant associated with premature birth

Abstract

The research includes studying of some proteins and enzymes levels in amniotic fluid for pregnant associated with premature birth, which includes C-reactive protein (CRP), alpha-fetoprotein (AFP), cystatin C, aminoacylase-1(ACY1), Lactate-dehydrogenase (LDH), aspartate aminotransferase (AST) and alanine aminotransferase (ALT). The study was done in Mosul city on (75) women that had hypertension, and (78) women who healthy pregnancies as a control group, the age of pregnant with hypertension and control group ranged from (16-45) year, then specimens were divided into three age groups: The first group (16-25) year, the second group (26-35) year and the third group (36-45) year. The results showed that there was a significant increase in the levels of proteins for CRP and AFP for all studied groups compared with a control group. On the other hand, the results of measurements of enzymes in the amniotic fluid indicated that there was a significant decrease in the activity of the ACY1 and a significant increase of enzymes: LDH, AST, and ALT in the amniotic fluid for pregnant associated with premature birth compared with the control group. High levels of CRP, cystin C, and AFP proteins, can be an indicator of diseases that accompany pregnant women, especially pregnant women with preterm birth. There are clear negative effects about the enzyme variants used to assess liver function in the amniotic fluid of preterm pregnant patients.