Pulmonary Arterial Hypertension In Congenital Heart Disease Could it be Normalized ? 11 years prospective study (2010-2021)


  • Rasmia H. Feituri
  • Mariam El maadani
  • Hanan El Megasbi
  • Amal Khazmi Khazmi
  • Ibrahim Nabous




pulmonary arterial hypertension, congenital heart disease, sildenafil, surgical intervention


Objective: To recognize the effect of early surgical intervention in congenital heart in improving pulmonary hypertension, and to show the result of using medication in decreasing pulmonary hypertension Background : Pulmonary hypertension is defined as a mean pulmonary arterial pressure ≥25 mmgh .in congenital heart disease (PAH-CHD)it is caused by pulmonary overcirculation, pulmonary vasoconstriction, and pulmonary vascular disease, either alone or in combination. Design prospective clinical trial study with follow up. Setting: Al-Hawary General Hospital, National Benghazi Cardiac Center. Methods: 68 patients have been seen with  pulmonary hypertension due to congenital heart disease in the period from 6/2010- 6/2021, Age: from 6 months to 40 years old, We exclude 4 patients with primary pulmonary hypertension, we used clinical criteria, echocardiogram, and cardiac  catheterization. Follow up method: period  3 months – 11 years, 4/68 patients lost their contact, we divide the other 64 patients into two the groups; Group 1 (n=  34)  <2 years old , Group 2  (n= 30)  >2 years old. Results: Gender: F: M ratio is approximately 1.3 :1. The type of congenital heart disease was in (48.5%)of patients VSD, in (28%) AVC, (8.5%)ASD, (4.5%) TPVDA, (3%) TGA, (3%) complex,(1.5%) univentricle, (1.5%) PDA,(1.5%) intramitral valve membrane MS. (34%) were Down syndrome patients, 37/68 received  sildenafil , 1/68  Bosentan, and 3/68 received  both drugs. Follow up results: Group 1 28/34 (82%) PHT normalized, 26/28 post operative, Group2 results:(10%) PHT normalized after surgery, Conclusions: The best therapy for PAH-CHD remains prevention through a “timely” repair of the defect., advanced medications are required.


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How to Cite

Feituri , R. H. ., El maadani, M. . ., El Megasbi, H. ., Khazmi , A. K. ., & Nabous , I. . (2021). Pulmonary Arterial Hypertension In Congenital Heart Disease Could it be Normalized ? 11 years prospective study (2010-2021). The Scientific Journal of University of Benghazi, 34(2). https://doi.org/10.37376/sjuob.v34i2.3238



Medical Sciences