The Impact of Age on Breast Cancer Incidence Among Libyan Women: A Meta-Analysis.
DOI:
https://doi.org/10.37376/sjuob.v38i1.7327Keywords:
Breast Cancer, Meta-Analysis, Age Factor, Heterogeneity, Random-Effects, Model, Incidence Rate, Libyan WomenAbstract
This meta-analysis, which draws on eight original studies, looks at the average age of Libyan women diagnosed with breast cancer. A full review of the original articles published in English between October 2016 and August 2024. A systematic review of five main databases was conducted to identify studies including Embase, Scopus, PubMed, Google Scholar and Web of Science. Only studies with unambiguous age data were included, as determined by the Population, Exposure, Comparator, Outcome, and Study Design (PECOS) criteria. The effect sizes were pooled using a random-effects model, and heterogeneity was measured with Cochran’s Q and I² statistics. The pooled mean age across studies was 47.81 years (95% CI: 46.87–48.74), indicating high variability (I² = 98.1%). Influence diagnostics identified one outlier study that contributed to the high heterogeneity. These findings highlight age distribution patterns in breast cancer cases in Libya, suggesting avenues for targeted early intervention strategies. Overall, these findings emphasize the demand for age-specific screening programs in Libya.Downloads
References
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.
Ferlay J, Ervik M, Lam F, Colombet M, Mery L, Piñeros M. Global cancer observatory: Cancer today. Lyon: International Agency for Research on Cancer; 2019.
Elgadi A, Benhalima I, Ghanem S, Badi S, Bedri O, Elzouki NA. Cancer epidemiology and control in Libya: A regional comparison and policy implications. J Glob Oncol. 2021 doi:10.1200/GO.21.00020.
Elzouki AN, Elgadi A, Benyahia R, Elkhammas EA, Bedri O, Benhalima I. Breast cancer epidemiology in Libya: Regional trends and emerging patterns. Libyan J Med. 2020;15(1):1–7
World Health Organization. Breast cancer: Prevention and control. Geneva: WHO; 2020
Anderson BO, Yip CH, Smith RA, Shyyan R, Sener SF, Eniu A. Breast cancer in limited-resource countries: Health care systems and public policy. Breast J. 2014;20(Suppl 1):S67–74
Al-Hamidi F, Alabed H, Sghaier W, Almisurati M, El-hadi A, Ghaith A. Age distribution and breast cancer subtypes among Libyan women: A hospital-based study. East Mediterr Health J. 2019;25(5):314–21
Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. Introduction to meta-analysis. Chichester: Wiley; 2009
Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ. Cochrane handbook for systematic reviews of interventions. 2nd ed. Chichester: Cochrane Collaboration; 2021
ElJilani M, Shebani A, Bishr A, Jalil H, et al. Assessment of breast cancer in Libyan women using Gail model. Libyan J Med Sci 2020;4:115‐9
Khetresh M. Breast cancer and its risk factors awareness, knowledge and beliefs among Libyan women resident in Zawia. University Bulletin. 2022;24(2):329-346.
Taher YA, Samud AM, Benhusein GM. Knowledge towards breast cancer among Libyan women in Tripoli. Libyan International Medical University Journal. 2016;1:58-68
El Ashouri A, Smeo M, Sabei L, Aldwebi H, AbuBaker N, Abu-khatwa M, Madi Q. Breast cancer delay presentation among Libyan patients: Demographic and clinical features. Mediterranean Journal of Pharmacy and Pharmaceutical Sciences. 2024; 4 (2): 30-36
Gaber M, Alamouri I, Alshybani H, Atneisha A, Omar F, Asselhab S, Ali A, Elfagieh M, Alragig M, Ben Saud M, Assidi M, Buhmeida A, Erimah E. Diagnosis delay and predicated factors in Libyan women with breast cancer. Libyan International journal of Oncology.2023;2(2):67-81
Ameigaal S, Ageel A, Abdoarahem M. Association of risk factors with breast cancer in Libyan women. Al-Mukhtar Journal of Science. 2020; 35(3): 222-228
Kutrani H, Eltalhi S, Ashleik N. Predicting factors influencing survival of breast cancer patients using logistic regression of machine learning. Paper presented at the 7th International Conference on Engineering & MIS 2021, Almaty, Kazakhstan, October 11–13; pp. 1–6
Houssein N, Cancer incidence in Libya using estimates from GLOBOCAN2020. Series Med Case Rep Rev. 2024;2(4):1-5.
Schlichting JA, Soliman AS, Schairer C, et al. Breast cancer by age at diagnosis in the Gharbiah, Egypt, population-based registry compared to the United States surveillance, epidemiology, and end results program 2004–2008. BioMed Res Int, 2015;381574.
Missaoui N, Landolsi H, Jaidaine L, et al. Breast cancer in Central Tunisia: An Earlier Age at Diagnosis and Incidence Increase over a 15 Year Period. Breast J. 2012;18(3):289-91.
Mehdi I, Monem EA, Al Bahrani BJ, et al. Age at diagnosis of female breast cancer in Oman: Issues and implications. South Asian J Cancer. 2014;3(2):101-6.
Karim S, Ghalib H, Mohammed SA, et al. The incidence, age at diagnosis of breast cancer in the Iraqi Kurdish population and comparison to some other countries of Middle-East and West. Int J Surg. 2015;13:71-75.
Franco-Marina F, López-Carrillo L, Keating NL, et al. Breast cancer age at diagnosis patterns in four Latin American Populations: A comparison with North American countries. Cancer Epidemiol. 2015;39(6):831-7.
Kumar N, Ehsan S, Banerjee S, Perez CF, Lhuilier I. The unique risk factor profile of triple-negative breast cancer: a comprehensive meta-analysis. Oxford University Press. 2024;116(8):1210–1219.
Kajela L and Chaka EE. Determinates of breast cancer in Ethiopia: a systematic review and meta-analysis. Ecancer. 2023;17:1624.
Argenal RN, Baterna ML, pena CF, Ravina JN, Siozon MR. Risk factors of breast cancer among women: a meta-analysis. 12th National Convention on Statistics. 2019.
Ewertz M, Duffy SW, Adami HO, Kvåle G, Lund E, Meirik O, Mellemgaard A, Soini I, Tulinius H. Age at first birth, parity and risk of breast cancer: a meta-analysis of 8 studies from the Nordic countries. Int J Cancer. 1990;15;46(4):597-603.doi: 10.1002/ijc.2910460408. PMID: 2145231.
Liu H, Shi S, Gao J, et al. Analysis of risk factors associated with breast cancer in women: a systematic review and meta-analysis. Transl Cancer Res, 2022; 11(5):1344-1353 | https://dx.doi.org/10.21037/tcr-22-193.
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