Evaluation of effects of white vinegar- induced gastric mucosal ulceration in rats

Abstract

This study was aimed to investigate the effects of white vinegar (WV) induced gastric mucosal ulceration in rats. Thirty rats were divided into three groups, group (1) was given distilled water as control group, group (2) was given WV with a dose [1 ml/kg (5%)] and group (3) was given WV with a dose [1 ml/kg (10%)] for 14 days. Results presented a significant decrease in the body weights and pH value of the gastric juice whereas, a significant increase occurred in gastric acid volume levels, total acidity, ulcer index and an ulcer score of stomach. Measurement of ulcer area of stomach showed, sever haemorrhagic areas covered with coagulated blood in group (3) while, group (2) showed, some spot ulcer and slight of haemorrhagic streaks compared with normal control group. The results of this study reveal that white vinegar has an effect on gastric mucosa from injury and ulcers in rats.